Graphical Abstracts
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Graphical Abstracts Current Drug Therapy, 2014, Vol. 9, No. 4 Graphical Abstracts Current Drug Therapy, 2014, Vol. 9, No. 4 210 Metal Based Pharmacological Active Agents: Structural, Electrochemical, DNA Binding Studies and Antibacterial Properties Harun Muslu, Derya Kılıçaslan, Mustafa Çeşme, Ayşegül Gölcü* and Sibel Özkan * University of Kahramanmaraş Sutcu Imam, Faculty of Science and Arts, Department of Chemistry, Campus of Avsar, 46100, Kahramanmaras, Turkey UV spectra of (a) 4 ppm EB, (b): a + 15 ppm DNA, (c): b + 2 ppm [Fe(ENO)2CI2], (d): b + 15 ppm [Fe(ENO)2CI2]. Current Drug Therapy, 2014, Vol. 9, No. 4 Poloxamer/Chitosan In Situ Gelling System for Ocular Delivery of Ofloxacin Ayşegül Karataş*, Ahsen Bölük and Aslıhan Hilal Algan * Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 06100, Ankara-Turkey 120 100 % Released 80 60 40 20 FA FB FD FE FC 0 0 50 100 Time (min) Drug release profiles of in situ gelling system including ofloxacin. 150 200 219 i ii Current Drug Therapy, 2014, Vol. 9, No. 4 Graphical Abstracts Current Drug Therapy, 2014, Vol. 9, No. 4 226 Electroanalytical Determination of Benzoic, Oxalic and Glyoxylic Acids Using Platinum Electrode M. Khodari*, Gaber A. M. Mersal, Ahmed A. Abd El-Raady and Beshary El-Desuki * Chemistry Department, Faculty of Science, South Valley University, Qena, Egypt Mechanism of reaction of glyoxylic acid with the mediator (ferrocene) at platinum electrode. Current Drug Therapy, 2014, Vol. 9, No. 4 232 Determination of The Ionization Constant of Local Anaesthetics in Organic Solvent-Water Media by The Spectrofluorimetric Method S. Beniz Gündüz*, Eda Ediz and Zeynep Altinordu * Selçuk University Faculty of Science, Department of Chemistry, 42031, Campus-Konya/Turkey H3C H C 3 H N+ O O H N+ O O NH NH NH+ CH3 N CH3 DIBUCAINE (pKa = 7.04) CH 3 CH3 Graphical Abstracts Current Drug Therapy, 2014, Vol. 9, No. 4 Current Drug Therapy, 2014, Vol. 9, No. 4 239 Influence of Polymer Molecular Weight on in-vitro Characteristics and Cytotoxicity of Fulvestrant Loaded Nanoparticles Canan Hascicek*, Ceyda T. Sengel-Turk, Mehmet Gumustas, Sibel A. Ozkan, Filiz Bakar, Net Das-Evcimen, Ayhan Savaser and Yalcin Ozkan * Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Ankara, Turkey FESEM micrographs of PNPs prepared with (A) low MW (B) high MW of PLGA. Current Drug Therapy, 2014, Vol. 9, No. 4 Design of Potentiometric Sensors Based on Interaction of Cyclodextrins with the Enantiomer of Interest Raluca-Ioana Stefan-van Staden*, Rahel Girmai Bokretsion, Jacobus Frederick van Staden and Hassan Y. Aboul-Enein * Laboratory of Electrochemistry and PATLAB Bucharest, National Institute of Research for Electrochemistry and Condensed Matter, 202 Splaiul Independentei Str., 060021, Bucharest, Romania 250 iii iv Current Drug Therapy, 2014, Vol. 9, No. 4 Graphical Abstracts Current Drug Therapy, 2014, Vol. 9, No. 4 256 Determination and Validation of the Antiviral Drugs using Reverse Phase High Performance Liquid Chromatographic Method Sevinc Kurbanoglu, Amir M. Ashrafi, Karel Vytřas, Bengi Uslu and Sibel A. Ozkan* * Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, 06100, Tandogan, Ankara, Turkey mAu 25 20 15 10 5 0 3 2 1 4 5 6 min Chromatograms of increasing concentrations of A) ABA in the presence of 5 µg.mL-1 FOS as IS. Current Drug Therapy, 2014, Vol. 9, No. 4 261 Investigation of the Metal Bonding Properties of Fluoroquinolone Type Antibiotics Using Spectrofluorimetric Method S. Beniz Gündüz*, Sevil Çan and Sibel A. Özkan * Selçuk University Faculty of Science, Department of Chemistry, 42031, Campus-Konya/Turkiye 465,0 LEV 400 Fluorescence Intensity 350 300 250 Addition of Fe(I II) ions 200 150 100 50 0,0 410,0 450 500 550 Wavelength, nm 600 650,0 Fluorescence emission spectrum of LEV (10-4 M) in aqueous solution and the apparent decrease of LEV fluorescence intensity with the addition of Fe(III) ions. 57. Graphical Abstracts Current Drug Therapy, 2014, Vol. 9, No. 4 Current Drug Therapy, 2014, Vol. 9, No. 4 270 Optimization and Application of Imprinted Poly(AA-EGDMA) for Solid Phase Extraction of Ciprofloxacin in Artificial Urine Luis D. Marestoni, Ademar Wong, Gustavo T. Feliciano, Mary R.R. Marchi, Cesar R.T. Tarley and Mariadel del Pilar Taboada Sotomayor* * Institute of Chemistry, São Paulo State University, Prof. Francisco Degni Street, 55, Quitandinha, Araraquara/SP - zip code 14800-900 Synthetic urine Bulk synthesis Thetmal initiation MISPE: Conditioning - Methanol - MilliQ3 water Sample Elution - MilliQ3 water - Acetonitrile - Methanol Acetic acid Filter the supernatant (0.45 mm) Reconstitution with methanol Evaporate to dryness Inject 20 ml extract sample to UPLC-UV-Vis Current Drug Therapy, 2014, Vol. 9, No. 4 Liquid Chromatographic, Spectrophotometric and Potentiometric pKa Determination of Ranitidine and Famotidine Y. Doğan Daldal, Cansel Çakır, Hülya Yılmaz, Ebru Çubuk Demiralay*, Sibel A. Özkan and Güleren Alsancak * Süleyman Demirel University, Science&Literature Faculty, Department of Chemistry, 32260, Isparta, Turkey 277 v vi Current Drug Therapy, 2014, Vol. 9, No. 4 Graphical Abstracts Current Drug Therapy, 2014, Vol. 9, No. 4 285 Investigation of the Metal Bonding Properties of Some ARA-II Compounds Using Spectrofluorimetric Method S. Beniz Gündüz* and Ahmet Dönertaş * Selçuk University Faculty of Science, Department of Chemistry, 42031, Campus-Konya/Türkiye 1000,0 VAL 900 800 Fluorescence Intensity 700 600 500 Addition of Cu (II) ion 400 300 200 100 0,0 300,0 350 400 450 Wavelenghth.nm 500 525,0 Fluorescence emission spectrum of VAL (10-5 M) in methanol and the apparent decrease of VAL fluorescence intensity with the addition of Cu(II) ions. 30. Current Drug Therapy, 2014, Vol. 9, No. 4 294 Enhanced Bioavailability of Cinnarizine Using Solid Dispersion: In Vitro and In Vivo Evaluation Muzeyyeu Demirel*, Gulary Büyükköroğlu, Basar Sırmagül, Bahar S. Kalava, N. Öztürk and Yesmin Yazan * Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Eskişehir, Turkey CN PEG 4000 F1 F3 F5 F7 PM 50 100 Temp (C) 150 DSC thermograms of: CN, PEG 4000, CN SDs prepared with PEG 4000 and physical mixture (PM).